Mitochondrial DNA homeostasis: A novel therapeutic target for neurodegenerative diseases

The mitochondrial genomic homeostasis is essential for the function of the oxidative phosphorylation system and cellular homeostasis. Mitochondrial DNA is particularly susceptible to aging-related oxidative stress due to the lack of a histone coat. Disturbances in mitochondrial DNA may contribute to...

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Autors principals:	Tingting Fu, Xinyi Chen, Shuting Zhang, Ying Fu, Ling Huang, Wandi Xiong
Format:	Artigo
Idioma:	Inglês
Publicat:	Wolters Kluwer Medknow Publications 2026-09-01
Col·lecció:	Neural Regeneration Research
Matèries:	aging alzheimer’s disease heteroplamy mitochondrial dna mutation mitochondrial dna mitochondrial genome mitochondrial haplogroup mitochondrial homeostasis neurodegenerative diseases parkinson’s disease
Accés en línia:	https://journals.lww.com/10.4103/NRR.NRR-D-25-00495
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