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Mitochondrial DNA homeostasis: A novel therapeutic target for neurodegenerative diseases

The mitochondrial genomic homeostasis is essential for the function of the oxidative phosphorylation system and cellular homeostasis. Mitochondrial DNA is particularly susceptible to aging-related oxidative stress due to the lack of a histone coat. Disturbances in mitochondrial DNA may contribute to...

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Hoofdauteurs: Tingting Fu, Xinyi Chen, Shuting Zhang, Ying Fu, Ling Huang, Wandi Xiong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Wolters Kluwer Medknow Publications 2026-09-01
Reeks:Neural Regeneration Research
Onderwerpen:
aging
alzheimer’s disease
heteroplamy
mitochondrial dna mutation
mitochondrial dna
mitochondrial genome
mitochondrial haplogroup
mitochondrial homeostasis
neurodegenerative diseases
parkinson’s disease
Online toegang:https://journals.lww.com/10.4103/NRR.NRR-D-25-00495
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