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Cell-free synthesis of amyloid fibrils with infectious properties and amenable to sub-milligram magic-angle spinning NMR analysis

A method for cell-free synthesis of amyloid fibrils is reported that also allows for solid-state NMR analysis to characterize complex and pathological fibrillary assemblies.

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Principais autores: Alons Lends, Asen Daskalov, Ansis Maleckis, Aline Delamare, Mélanie Berbon, Axelle Grélard, Estelle Morvan, Jayakrishna Shenoy, Antoine Dutour, James Tolchard, Abdelmajid Noubhani, Marie-France Giraud, Corinne Sanchez, Birgit Habenstein, Gilles Guichard, Guillaume Compain, Kristaps Jaudzems, Sven J. Saupe, Antoine Loquet
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2022-11-01
coleção:Communications Biology
Acesso em linha:https://doi.org/10.1038/s42003-022-04175-1
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