A systematic investigation of production of synthetic prions from recombinant prion protein

According to the protein-only hypothesis, infectious mammalian prions, which exist as distinct strains with discrete biological properties, consist of multichain assemblies of misfolded cellular prion protein (PrP). A critical test would be to produce prion strains synthetically from defined compone...

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Bibliografiske detaljer

Principais autores:	Christian Schmidt, Jeremie Fizet, Francesca Properzi, Mark Batchelor, Malin K. Sandberg, Julie A. Edgeworth, Louise Afran, Sammy Ho, Anjna Badhan, Steffi Klier, Jacqueline M. Linehan, Sebastian Brandner, Laszlo L. P. Hosszu, M. Howard Tattum, Parmjit Jat, Anthony R. Clarke, Peter C. Klöhn, Jonathan D. F. Wadsworth, Graham S. Jackson, John Collinge
Format:	Artigo
Sprog:	Inglês
Udgivet:	The Royal Society 2015-01-01
Serier:	Open Biology
Fag:	prion prion disease prion protein prion amyloid synthetic prions
Online adgang:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150165
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