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The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection

Dysfunction of the intestinal epithelial barrier causes microbial invasion that would lead to inflammation in the gut. Antimicrobial peptides (AMPs) are essential components of the intestinal epithelial barrier, while the regulatory mechanisms of AMPs expression are not fully characterized. Here, we...

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Principais autores: Keying Yu, Yu-Yao Guo, Tianzi Liuyu, Peng Wang, Zhi-Dong Zhang, Dandan Lin, Bo Zhong
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2023-06-01
סדרה:Cell Insight
נושאים:
OTUD4
Colitis
Bacterial infection
Antimicrobial peptides
MyD88
Deubiquitination
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S277289272300024X
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