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Branched‐Chain Amino Acids Mediate the Regulation of SACE_Lrp on the Aminotransferase IlvE Involved in Erythromycin Biosynthesis in Saccharopolyspora erythraea

ABSTRACT Erythromycin is a broad‐spectrum polyketide antibiotic which can be obtained mainly through biosynthesis. The catabolic pathway of branched‐chain amino acids (BCAAs) significantly influences the biosynthesis of erythromycin. However, the regulatory mechanisms controlling the BCAA catabolic...

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Principais autores: Xinlu Cai, Lijuan Tang, Yinuo Liu, Youquan Zou, Xueyan Li, Haoyang He, Youya Tang, Endong Yang, Buchang Zhang, Jing Liu
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-04-01
Serier:Microbial Biotechnology
Fag:
aminotransferase IlvE
branched‐chain amino acid
erythromycin biosynthesis
SACE_Lrp regulator
Online adgang:https://doi.org/10.1111/1751-7915.70344
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