A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer

Abstract Background Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradually develops into an androgen-resistant metastatic state in the vast m...

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Autors principals:	Ioanna Mourkioti, Aikaterini Polyzou, Dimitris Veroutis, George Theocharous, Nefeli Lagopati, Emanuela Gentile, Vasiliki Stravokefalou, Dimitris-Foivos Thanos, Sophia Havaki, Dimitris Kletsas, Theocharis Panaretakis, Christopher J. Logothetis, Dimitris Stellas, Russell Petty, Giovanni Blandino, Angelos Papaspyropoulos, Vassilis G. Gorgoulis
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2023-07-01
Col·lecció:	Journal of Experimental & Clinical Cancer Research
Matèries:	Prostate cancer AR signaling blockade Enzalutamide GATA2-CDC6 axis Cellular senescence
Accés en línia:	https://doi.org/10.1186/s13046-023-02769-z
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