Licorice-derived prenylated chalcones alleviate knee osteoarthritis via multi-target modulation of PI3K-Akt, MAPK and HIF-1α signaling: an integrative UPLC-Q-TOF-MS/MS, network pharmacology and molecular dynamics study
Knee osteoarthritis (KOA) remains a leading cause of global disability, yet no disease-modifying osteoarthritis drug (DMOAD) has been approved. This exploratory computational study aimed to elucidate the potential bioactive basis and mechanism of action of a clinically used licorice extract against...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Frontiers Media S.A.
2026-05-01
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| Collection: | Frontiers in Bioinformatics |
| Sujets: | |
| Accès en ligne: | https://www.frontiersin.org/articles/10.3389/fbinf.2026.1805739/full |
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