Licorice-derived prenylated chalcones alleviate knee osteoarthritis via multi-target modulation of PI3K-Akt, MAPK and HIF-1α signaling: an integrative UPLC-Q-TOF-MS/MS, network pharmacology and molecular dynamics study
Knee osteoarthritis (KOA) remains a leading cause of global disability, yet no disease-modifying osteoarthritis drug (DMOAD) has been approved. This exploratory computational study aimed to elucidate the potential bioactive basis and mechanism of action of a clinically used licorice extract against...
Zapisane w:
| Główni autorzy: | , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Frontiers Media S.A.
2026-05-01
|
| Seria: | Frontiers in Bioinformatics |
| Hasła przedmiotowe: | |
| Dostęp online: | https://www.frontiersin.org/articles/10.3389/fbinf.2026.1805739/full |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|