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The Dynamics of SecM-Induced Translational Stalling

SecM is an E. coli secretion monitor capable of stalling translation on the prokaryotic ribosome without cofactors. Biochemical and structural studies have demonstrated that the SecM nascent chain interacts with the 50S subunit exit tunnel to inhibit peptide bond formation. However, the timescales a...

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Autors principals: Albert Tsai, Guy Kornberg, Magnus Johansson, Jin Chen, Joseph D. Puglisi
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014-06-01
Col·lecció:Cell Reports
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2211124714003350
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