Body‐Wide Inactivation of the Myc‐Like Mlx Transcription Factor Network Accelerates Aging and Increases the Lifetime Cancer Incidence

Abstract The “Mlx” and “Myc” transcription factor networks cross‐communicate and share many common gene targets. Myc's activity depends upon its heterodimerization with Max, whereas the Mlx Network requires that the Max‐like factor Mlx associate with the Myc‐like factors MondoA or ChREBP. The curren...

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Ngā kaituhi matua:	Huabo Wang, Taylor Stevens, Jie Lu, Alexander Roberts, Clinton Van't Land, Radhika Muzumdar, Zhenwei Gong, Jerry Vockley, Edward V. Prochownik
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2024-09-01
Rangatū:	Advanced Science
Ngā marau:	glycolysis mitochondria reactive oxygen species TCA cycle telomeres Warburg effect
Urunga tuihono:	https://doi.org/10.1002/advs.202401593
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!