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Overexpression of the RNA-binding protein NrdA affects global gene expression and secondary metabolism in Aspergillus species

ABSTRACT RNA-binding protein Nrd1 plays a role in RNA polymerase II transcription termination. In this study, we showed that the orthologous NrdA is important in global mRNA expression and secondary metabolism in Aspergillus species. We constructed an nrdA conditional expression strain using the Tet...

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Uloženo v:
Hlavní autoři: Chihiro Kadooka, Kosuke Izumitsu, Teigo Asai, Kentaro Hiramatsu, Kazuki Mori, Kayu Okutsu, Yumiko Yoshizaki, Kazunori Takamine, Masatoshi Goto, Hisanori Tamaki, Taiki Futagami
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2025-02-01
Edice:mSphere
Témata:
Aspergillus
RNA-binding protein
NrdA
gene expression
secondary metabolism
On-line přístup:https://journals.asm.org/doi/10.1128/msphere.00849-24
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