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Catalytic Proximal Protein Oligomerization as an Anti-Tumor Strategy Targeting WDR5

Abstract Inducing protein oligomerization holds therapeutic promise, yet identifying or rationally designing effective inducers remains challenging. In this study, we leverage nanopore technology to screen small molecules capable of modulating WD repeat domain 5 (WDR5) protein oligomerization and un...

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Автори: Yizheng Fang, Li Jiang, Feifan Wang, Yihui Zhou, Jie Cen, Yuxin Yang, Haiyang Wang, Qi Chen, Yushen Lin, Tingting Wang, Hongxia Xu, Yongping Yu, Chengliang Zhu, Qiaojun He, Bo Yang, Chun Zhou, Wenteng Chen, Longhua Tang, Ji Cao
Формат: Artigo
Мова:Inglês
Опубліковано: Nature Portfolio 2026-03-01
Серія:Nature Communications
Онлайн доступ:https://doi.org/10.1038/s41467-026-70409-z
Теги: Додати тег
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