Catalytic Proximal Protein Oligomerization as an Anti-Tumor Strategy Targeting WDR5

Abstract Inducing protein oligomerization holds therapeutic promise, yet identifying or rationally designing effective inducers remains challenging. In this study, we leverage nanopore technology to screen small molecules capable of modulating WD repeat domain 5 (WDR5) protein oligomerization and un...

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Bibliografiske detaljer

Principais autores:	Yizheng Fang, Li Jiang, Feifan Wang, Yihui Zhou, Jie Cen, Yuxin Yang, Haiyang Wang, Qi Chen, Yushen Lin, Tingting Wang, Hongxia Xu, Yongping Yu, Chengliang Zhu, Qiaojun He, Bo Yang, Chun Zhou, Wenteng Chen, Longhua Tang, Ji Cao
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-03-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-026-70409-z
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