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The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells

Acquisition of pluripotency is driven largely at the transcriptional level by activators OCT4, SOX2, and NANOG that must in turn cooperate with diverse coactivators to execute stem cell-specific gene expression programs. Using a biochemically defined in vitro transcription system that mediates OCT4/...

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Principais autores: Yick W Fong, Jaclyn J Ho, Carla Inouye, Robert Tjian
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2014-11-01
Serier:eLife
Fag:
transcriptional coactivator
pluripotency
embryonic stem cell
non-coding RNA
induced pluripotent stem cell
priviledged somatic cell state
Online adgang:https://elifesciences.org/articles/03573
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