Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium

Abstract Background Genetic disruption of slc4a10, which encodes the sodium-dependent chloride/bicarbonate exchanger Ncbe, leads to a major decrease in Na+-dependent HCO3 − import into choroid plexus epithelial cells in mice and to a marked reduction in brain intraventricular fluid volume. This sugg...

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Autori principali:	Inga Baasch Christensen, Qi Wu, Anders Solitander Bohlbro, Marianne Gerberg Skals, Helle Hasager Damkier, Christian Andreas Hübner, Robert Andrew Fenton, Jeppe Praetorius
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2020-01-01
Serie:	Fluids and Barriers of the CNS
Soggetti:	Choroid plexus Cerebrospinal fluid Ncbe Mass spectrometry
Accesso online:	https://doi.org/10.1186/s12987-019-0162-5
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