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Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium

Abstract Background Genetic disruption of slc4a10, which encodes the sodium-dependent chloride/bicarbonate exchanger Ncbe, leads to a major decrease in Na+-dependent HCO3 − import into choroid plexus epithelial cells in mice and to a marked reduction in brain intraventricular fluid volume. This sugg...

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Principais autores: Inga Baasch Christensen, Qi Wu, Anders Solitander Bohlbro, Marianne Gerberg Skals, Helle Hasager Damkier, Christian Andreas Hübner, Robert Andrew Fenton, Jeppe Praetorius
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-01-01
Serier:Fluids and Barriers of the CNS
Fag:
Choroid plexus
Cerebrospinal fluid
Ncbe
Mass spectrometry
Online adgang:https://doi.org/10.1186/s12987-019-0162-5
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