VX‐765 ameliorates renal injury and fibrosis in diabetes by regulating caspase‐1‐mediated pyroptosis and inflammation
Abstract Introduction As a lytic inflammatory cell death, pyroptosis has been recently described but has not been unequivocally elucidated in diabetic nephropathy (DN). VX‐765 is a safe and effective inhibitor of caspase‐1, that was well tolerated in a phase II clinical trial in patients with epilep...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Wiley
2022-01-01
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| Seria: | Journal of Diabetes Investigation |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1111/jdi.13660 |
| Etykiety: |
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