A peptide display system identifies a potent mutant β-melanocyte-stimulating hormone agonist of melanocortin-4 receptor

Summary: Non-olfactory G-protein-coupled receptors (GPCRs) regulate vital physiological functions and are targets for ∼34% of US Food and Drug Administration (FDA)-approved drugs. While small-molecule-activated GPCRs are well studied, there is growing interest in peptide GPCRs, particularly the mela...

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Главные авторы:	Ann Lin, Kaitlyn Spees, Raeline Valbuena, Jakob Wirbel, Aravind Natarajan, Nora Enright, Ami S. Bhatt, Michael C. Bassik
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-11-01
Серии:	Cell Genomics
Предметы:	MC4R peptide display scanning mutagenesis
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2666979X25002447
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