The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives

The melanocortin system is a genetically conserved and clinically validated target for the treatment of obesity. Hundreds of studies establish the role of the melanocortin receptors, particularly the melanocortin-4 receptor, in food intake, weight control, and energy expenditure. Over the last sever...

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Autores principales:	Claudia R. Prindle, Thomas L. Bennett, Benjamin H. Rajewski, Kade J. Kelley, Anna C. Impastato, Russell Potterfield, Daniel L. Marks, Jordan Y. Delev
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Colección:	Frontiers in Endocrinology
Materias:	food intake melanocortin (MC) melanocortin-3 receptor melanocortin-4 receptor melanocortin-4 receptor agonist metabolism
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fendo.2026.1797586/full
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