Chemotranscriptomic Profiling Defines Drug-Specific Signatures of the Glycopeptide Antibiotics Dalbavancin, Vancomycin and Chlorobiphenyl-Vancomycin in a VanB-Type-Resistant Streptomycete

Dalbavancin, vancomycin and chlorobiphenyl-vancomycin share a high degree of structural similarity and the same primary mode of drug action. All inhibit bacterial cell wall biosynthesis through complexation with intermediates in peptidoglycan biosynthesis mediated via interaction with peptidyl-d-ala...

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Autors principals:	Andy Hesketh, Giselda Bucca, Colin P. Smith, Hee-Jeon Hong
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-02-01
Col·lecció:	Frontiers in Microbiology
Matèries:	glycopeptide antibiotic resistance vancomycin dalbavancin chemotranscriptomics
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.641756/full
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