Chemotranscriptomic Profiling Defines Drug-Specific Signatures of the Glycopeptide Antibiotics Dalbavancin, Vancomycin and Chlorobiphenyl-Vancomycin in a VanB-Type-Resistant Streptomycete

Dalbavancin, vancomycin and chlorobiphenyl-vancomycin share a high degree of structural similarity and the same primary mode of drug action. All inhibit bacterial cell wall biosynthesis through complexation with intermediates in peptidoglycan biosynthesis mediated via interaction with peptidyl-d-ala...

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Hlavní autoři:	Andy Hesketh, Giselda Bucca, Colin P. Smith, Hee-Jeon Hong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-02-01
Edice:	Frontiers in Microbiology
Témata:	glycopeptide antibiotic resistance vancomycin dalbavancin chemotranscriptomics
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.641756/full
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