Selective EV Protein Sorting and Pathway Perturbation in AML Upon Synergistic FLT3 and Hedgehog Pathway Inhibition

ABSTRACT Acute myeloid leukaemia (AML) is a haematologic malignancy with high relapse incidence and mortality. Approximately one‐third of AML patients carry an fms‐like tyrosine kinase 3 (FLT3) mutation, often associated with GLI expression and Hedgehog signalling. AML cells shape their microenviron...

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Principais autores:	Constantin Blöchl, Gabriele Blümel, Martin Wolf, Christof Regl, Heide‐Marie Binder, Suzana Tesanovic, Daniel Lankes, Nicole Maeding, Peter W. Krenn, Dirk Strunk, Fritz Aberger, Christian G. Huber
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2025-09-01
Serija:	Journal of Extracellular Vesicles
Teme:	AML crenolanib ErbB signalling EVs Hedgehog HPI‐1
Online dostop:	https://doi.org/10.1002/jev2.70163
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