Selective EV Protein Sorting and Pathway Perturbation in AML Upon Synergistic FLT3 and Hedgehog Pathway Inhibition

ABSTRACT Acute myeloid leukaemia (AML) is a haematologic malignancy with high relapse incidence and mortality. Approximately one‐third of AML patients carry an fms‐like tyrosine kinase 3 (FLT3) mutation, often associated with GLI expression and Hedgehog signalling. AML cells shape their microenviron...

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Autors principals:	Constantin Blöchl, Gabriele Blümel, Martin Wolf, Christof Regl, Heide‐Marie Binder, Suzana Tesanovic, Daniel Lankes, Nicole Maeding, Peter W. Krenn, Dirk Strunk, Fritz Aberger, Christian G. Huber
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-09-01
Col·lecció:	Journal of Extracellular Vesicles
Matèries:	AML crenolanib ErbB signalling EVs Hedgehog HPI‐1
Accés en línia:	https://doi.org/10.1002/jev2.70163
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