Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis

Abstract Background Acute myeloid leukemia (AML) is characterized by the abnormal proliferation of myeloid precursor cells and presents significant challenges in treatment due to its heterogeneity. Recently, the NLRP3 inflammasome has emerged as a potential contributor to AML pathogenesis, although...

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Bibliografiske detaljer

Principais autores:	Michela Luciano, Helene Sieberer, Peter W. Krenn, Hieu-Hoa Dang, Julia Vetter, Theresa Neuper, Diana Amend, Constantin Blöchl, Christian X. Weichenberger, Anna Eglseer, Michael S. Unger, Ancuela Andosch, Philip Steiner, Daniel Neureiter, Renate Bauer, Laura Hummer, Suzana Tesanovic, Stephanie Binder, Dominik P. Elmer, Helen Strandt, Susanne Schaller, Dirk Strunk, Lisa Pleyer, Richard Greil, Stephan Winkler, Tanja N. Hartmann, Dirk Schmidt-Arras, Christian G. Huber, Fritz Aberger, Jutta Horejs-Hoeck
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2024-09-01
Serier:	Cell Communication and Signaling
Fag:	Acute myeloid leukemia Apoptosis eIF2α, NLRP3 PERK
Online adgang:	https://doi.org/10.1186/s12964-024-01777-6
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