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Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1

Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates the SC G-protein coupled receptor (GPCR) P2Y2. Do...

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Principais autores: Robert A. Coover, Tabitha E. Healy, Li Guo, Katherine E. Chaney, Robert F. Hennigan, Craig S. Thomson, Lindsey E. Aschbacher-Smith, Michael P. Jankowski, Nancy Ratner
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2018-11-01
סדרה:Acta Neuropathologica Communications
נושאים:
Glia
Schwann
PP2A
AKT
Purinergic
Neurofibromatosis
גישה מקוונת:http://link.springer.com/article/10.1186/s40478-018-0635-9
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