Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1

Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates the SC G-protein coupled receptor (GPCR) P2Y2. Do...

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Bibliografske podrobnosti

Principais autores:	Robert A. Coover, Tabitha E. Healy, Li Guo, Katherine E. Chaney, Robert F. Hennigan, Craig S. Thomson, Lindsey E. Aschbacher-Smith, Michael P. Jankowski, Nancy Ratner
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2018-11-01
Serija:	Acta Neuropathologica Communications
Teme:	Glia Schwann PP2A AKT Purinergic Neurofibromatosis
Online dostop:	http://link.springer.com/article/10.1186/s40478-018-0635-9
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