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Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1

Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates the SC G-protein coupled receptor (GPCR) P2Y2. Do...

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Wedi'i Gadw mewn:
Prif Awduron: Robert A. Coover, Tabitha E. Healy, Li Guo, Katherine E. Chaney, Robert F. Hennigan, Craig S. Thomson, Lindsey E. Aschbacher-Smith, Michael P. Jankowski, Nancy Ratner
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2018-11-01
Cyfres:Acta Neuropathologica Communications
Pynciau:
Glia
Schwann
PP2A
AKT
Purinergic
Neurofibromatosis
Mynediad Ar-lein:http://link.springer.com/article/10.1186/s40478-018-0635-9
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