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Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting

Abstract Background Genome editing by CRISPR-Cas9 technology allows large-scale screening of gene essentiality in cancer. A confounding factor when interpreting CRISPR-Cas9 screens is the high false-positive rate in detecting essential genes within copy number amplified regions of the genome. We hav...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Francesco Iorio, Fiona M. Behan, Emanuel Gonçalves, Shriram G. Bhosle, Elisabeth Chen, Rebecca Shepherd, Charlotte Beaver, Rizwan Ansari, Rachel Pooley, Piers Wilkinson, Sarah Harper, Adam P. Butler, Euan A. Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-08-01
Schriftenreihe:BMC Genomics
Schlagworte:
CRISPR-Cas9
Genetic screens
Cancer
Gene copy number
Bias correction
Online-Zugang:http://link.springer.com/article/10.1186/s12864-018-4989-y
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