Obesity modulates hematopoietic stem cell fate decision via IL-1β induced p38/MAPK signaling pathway

Abstract Background Obesity is accompanied by inflammation, which significantly affects the homeostasis of the immune microenvironment. Hematopoietic stem cells (HSCs), residing primarily in the bone marrow, play a vital role in maintaining and producing diverse mature blood cell lineages for the ad...

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Hlavní autoři:	Jinxiao Yan, Pan Zhang, Xiru Liu, Chengwei Pan, Guolin Shi, Penghui Ye, Xiaohang Zou, Xiang Li, Xinmin Zheng, Yu Liu, Hui Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-09-01
Edice:	Stem Cell Research & Therapy
Témata:	Obesity Inflammation Hematopoietic stem cells Bone marrow niche IL-1β
On-line přístup:	https://doi.org/10.1186/s13287-024-03915-w
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