Differential T cell immune responses to deamidated adeno-associated virus vector

Despite the high safety profile demonstrated in clinical trials, the immunogenicity of adeno-associated virus (AAV)-mediated gene therapy remains a major hurdle. Specifically, T-cell-mediated immune responses to AAV vectors are related to loss of efficacy and potential liver toxicities. As post-tran...

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Autors principals:	So Jin Bing, Sune Justesen, Wells W. Wu, Abdul Mohin Sajib, Stephanee Warrington, Alan Baer, Stephan Thorgrimsen, Rong-Fong Shen, Ronit Mazor
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-03-01
Col·lecció:	Molecular Therapy: Methods & Clinical Development
Matèries:	deamidation immunogenicity adeno-associated virus vector T cell epitopes gene therapy
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2329050122000067
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