Variation of VP2 stoichiometry and deamidation of VP1 during production and their impacts on the transduction efficiency of AAV vectors

Recombinant adeno-associated viruses (rAAVs) are a leading platform for in vivo gene therapy. However, limited information is available on the fluctuation of quality attributes (QAs), during manufacturing using the HEK293 suspension cell line system, which is suitable for small- to large-scale produ...

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প্রধান লেখক:	Takahiro Maruno, Mitsuko Fukuhara, Yasuo Tsunaka, Aoba Matsushita, Kiichi Hirohata, Karin Bandoh, Megumi Onaka, Risa Shibuya, Yuki Yamaguchi, Haruka Nishiumi, Yoshiki Nagashima, Daisuke Higo, Toshie Kuwahara, Tomoko Ueno, Masaharu Maeda, Guirong Kanai-Bai, Noriko Yamano-Adachi, Tetsuo Torisu, Takeshi Omasa, Susumu Uchiyama
বিন্যাস:	Artigo
ভাষা:	Inglês
প্রকাশিত:	Elsevier 2025-12-01
মালা:	Molecular Therapy: Methods & Clinical Development
বিষয়গুলি:	gene therapy adeno-associated virus vector AAV vector vector manufacturing viral protein stoichiometry deamidation
অনলাইন ব্যবহার করুন:	http://www.sciencedirect.com/science/article/pii/S2329050125001767
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