Determination of Deamidation in Adjuvanted Vaccine Antigens through Isoaspartic Acid Quantification

Deamidation is a post-translational chemical modification that occurs within proteins and can be influenced by many factors, including temperature and pH. In vaccines, deamidation is considered undesirable as it may lead to changes in structure, function, stability, and immunogenicity. Detecting dea...

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Detalhes bibliográficos

Principais autores:	Manvi Hasija, Jian Ma, Bing Li, Nausheen Rahman, Kirsten A. Strahlendorf, Salvador Fernando Ausar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-07-01
coleção:	Vaccines
Assuntos:	vaccine stability deamidation formulation isoaspartic acid degradation
Acesso em linha:	https://www.mdpi.com/2076-393X/12/7/733
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