Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability
The design of free-flowing lyophilized powders by spray-freeze-drying (SFD) enables novel therapeutic applications, including nasal administration. In this study, a non-aqueous SFD approach using dimethyl sulfoxide (DMSO) as the spray solvent was investigated. Low-viscosity hydroxypropyl cellulose g...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2026-06-01
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| Schriftenreihe: | International Journal of Pharmaceutics: X |
| Schlagworte: | |
| Online-Zugang: | http://www.sciencedirect.com/science/article/pii/S259015672600071X |
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