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Motor transmission defects with sex differences in a new mouse model of mild spinal muscular atrophy

Background: Mouse models of mild spinal muscular atrophy (SMA) have been extremely challenging to generate. This paucity of model systems has limited our understanding of pathophysiological events in milder forms of the disease and of the effect of SMN depletion during aging. Methods: A mild mouse m...

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Kaydedildi:
Asıl Yazarlar: Marc-Olivier Deguise, Yves De Repentigny, Alexandra Tierney, Ariane Beauvais, Jean Michaud, Lucia Chehade, Mohamed Thabet, Brittany Paul, Aoife Reilly, Sabrina Gagnon, Jean-Marc Renaud, Rashmi Kothary
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2020-05-01
Seri Bilgileri:EBioMedicine
Konular:
Aging
SMN
Type IV
Electrophysiology
Sex difference
Non-neuronal defects
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2352396420301250
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