Defects in neuromuscular junction remodelling in the Smn2B/− mouse model of spinal muscular atrophy

Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease caused by mutations and deletions within the survival motor neuron 1 (SMN1) gene. Although other tissues may be involved, motor neurons remain primary pathological targets, with loss of neuromuscular junctions (NMJs) repre...

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Auteurs principaux:	Lyndsay M. Murray, Ariane Beauvais, Kunal Bhanot, Rashmi Kothary
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2013-01-01
Collection:	Neurobiology of Disease
Sujets:	Neuromuscular junction Spinal muscular atrophy Remodelling Sprouting Endplate Schwann cell
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S0969996112003063
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