DNA polymerase eta participates in the mutagenic bypass of adducts induced by benzo[a]pyrene diol epoxide in mammalian cells.

Y-family DNA-polymerases have larger active sites that can accommodate bulky DNA adducts allowing them to bypass these lesions during replication. One member, polymerase eta (pol eta), is specialized for the bypass of UV-induced thymidine-thymidine dimers, correctly inserting two adenines. Loss of p...

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Detalhes bibliográficos

Principais autores:	Alden C Klarer, L Jay Stallons, Tom J Burke, Robert L Skaggs, W Glenn McGregor
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2012-01-01
Colecção:	PLoS ONE
Acesso em linha:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039596&type=printable
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