Reducing the Periplasmic Glutathione Content Makes Escherichia coli Resistant to Trimethoprim and Other Antimicrobial Drugs
ABSTRACT Although glutathione (GSH) has been shown to influence the antimicrobial effects of many kinds of antibiotics, little is known about its role in relation to trimethoprim (TMP), a widely used antifolate. In this study, several genes related to glutathione metabolism were deleted in different...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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American Society for Microbiology
2021-12-01
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| Schriftenreihe: | Microbiology Spectrum |
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| Online-Zugang: | https://journals.asm.org/doi/10.1128/Spectrum.00743-21 |
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