Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms
Hitomi Matsuzaki et al. test the effect of reversing the H19/Igf2 imprinting control region (ICR) in mice. Their results suggest that the polarity of the ICR is involved in controlling imprinted H19 expression in both parental alleles, dependent or independent of DNA methylation.
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2021-12-01
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| Serie: | Communications Biology |
| Accesso online: | https://doi.org/10.1038/s42003-021-02939-9 |
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