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Aging-associated transcriptional programs in T cells signify constituents of TGF-β signaling for immunosenescence

Abstract Background Immunosenescence, particularly the altered ratio of naïve and memory T cells, contributes to a diminished immune reserve and impaired adaptive immunity in aging and frail populations. The role of TGF-β signaling pathway—a critical hallmark of organismal senescence and T-cell exha...

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Bibliografiske detaljer
Principais autores: Renke He, Chanchan Xiao, Wen Lei, Guobing Chen, Yangqiu Li, Oscar Junhong Luo
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:BMC Biology
Fag:
Online adgang:https://doi.org/10.1186/s12915-025-02484-5
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