Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity
Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). The characterization of a novel mutation in Mre11 causing accelerated DSB res...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis Group
2018-09-01
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| Schriftenreihe: | Molecular & Cellular Oncology |
| Schlagworte: | |
| Online-Zugang: | http://dx.doi.org/10.1080/23723556.2018.1511208 |
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