Trypanosoma cruzi Mitochondrial Peroxiredoxin Promotes Infectivity in Macrophages and Attenuates Nifurtimox Toxicity

Trypanosoma cruzi is the causative agent of Chagas disease which is currently treated by nifurtimox (NFX) and benznidazole (BZ). Nevertheless, the mechanism of action of NFX is not completely established. Herein, we show the protective effects of T. cruzi mitochondrial peroxiredoxin (MPX) in macroph...

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Autors principals:	Gabriela Specker, Damián Estrada, Rafael Radi, Lucía Piacenza
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-02-01
Col·lecció:	Frontiers in Cellular and Infection Microbiology
Matèries:	T. cruzi nifurtimox mitochondrial peroxiredoxin macrophage infection holdase and peroxidase activities
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.749476/full
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