Trypanosoma cruzi Mitochondrial Peroxiredoxin Promotes Infectivity in Macrophages and Attenuates Nifurtimox Toxicity

Trypanosoma cruzi is the causative agent of Chagas disease which is currently treated by nifurtimox (NFX) and benznidazole (BZ). Nevertheless, the mechanism of action of NFX is not completely established. Herein, we show the protective effects of T. cruzi mitochondrial peroxiredoxin (MPX) in macroph...

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Principais autores:	Gabriela Specker, Damián Estrada, Rafael Radi, Lucía Piacenza
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-02-01
coleção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	T. cruzi nifurtimox mitochondrial peroxiredoxin macrophage infection holdase and peroxidase activities
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.749476/full
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