De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency

Summary: CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cells. Here, we conducted a comprehensive analysis of...

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Bibliografische Detailangaben

Hauptverfasser:	Masaki Yagi, Mio Kabata, Tomoyo Ukai, Sho Ohta, Akito Tanaka, Yui Shimada, Michihiko Sugimoto, Kimi Araki, Keisuke Okita, Knut Woltjen, Konrad Hochedlinger, Takuya Yamamoto, Yasuhiro Yamada
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2019-05-01
Schriftenreihe:	Stem Cell Reports
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2213671119301304
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