Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein.

Prions are infectious agents causing fatal neurodegenerative diseases of humans and animals. In humans, these have sporadic, acquired and inherited aetiologies. The inherited prion diseases are caused by one of over 30 coding mutations in the human prion protein (PrP) gene (PRNP) and many of these g...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Emmanuel A Asante, Jacqueline M Linehan, Michelle Smidak, Andrew Tomlinson, Andrew Grimshaw, Asif Jeelani, Tatiana Jakubcova, Shyma Hamdan, Caroline Powell, Sebastian Brandner, Jonathan D F Wadsworth, John Collinge
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Public Library of Science (PLoS) 2013-01-01
Sarja:	PLoS Pathogens
Linkit:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003643&type=printable
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!