npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease

Niemann-Pick type C (NPC) disease is an autosomal recessive lysosomal storage disease that is caused by a mutation of the NPC1 or NPC2 gene, in which un-esterified cholesterol and sphingolipids accumulate mainly in the liver, spleen, and brain. Abnormal lysosomal storage leads to cell damage, neurol...

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Hlavní autoři:	Malgorzata Wiweger, Lukasz Majewski, Dobrochna Adamek-Urbanska, Iga Wasilewska, Jacek Kuznicki
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-04-01
Edice:	Frontiers in Cellular Neuroscience
Témata:	Niemann-Pick type C npc2 zebrafish model Nile blue lysosomal storage disease neurodegeneration
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fncel.2021.647860/full
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