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Novel c-Jun N-Terminal Kinase (JNK) Inhibitors with an 11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-one Scaffold

c-Jun N-terminal kinase (JNK) plays a central role in stress signaling pathways implicated in important pathological processes, including rheumatoid arthritis and ischemia-reperfusion injury. Therefore, inhibition of JNK is of interest for molecular targeted therapy to treat various diseases. We syn...

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Huvudupphov: Serhii A. Liakhov, Igor A. Schepetkin, Olexander S. Karpenko, Hanna I. Duma, Nadiia M. Haidarzhy, Liliya N. Kirpotina, Anastasia R. Kovrizhina, Andrei I. Khlebnikov, Irina Y. Bagryanskaya, Mark T. Quinn
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2021-09-01
Serie:Molecules
Ämnen:
c-Jun N-terminal kinase
kinase inhibitor
11<i>H</i>-indeno[1,2-<i>b</i>]quinoxalin-11-one
oxime
interleukin-6
nuclear factor-κB
Länkar:https://www.mdpi.com/1420-3049/26/18/5688
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