Evaluation of Nitric Oxide-Donating Properties of 11<i>H</i>-indeno[1,2-<i>b</i>]quinoxalin-11-one Oxime (IQ-1) by Electron Paramagnetic Resonance Spectroscopy

IQ-1 (11<i>H</i>-indeno[1,2-<i>b</i>]quinoxalin-11-one oxime) is a specific c-Jun N-terminal kinase (JNK) inhibitor with anticancer and neuro- and cardioprotective properties. Because aryloxime derivatives undergo cytochrome P450-catalyzed oxidation to nitric oxide (NO) and ketones in liver microsom...

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Autores principales:	Viacheslav V. Andrianov, Igor A. Schepetkin, Leah V. Bazan, Khalil L. Gainutdinov, Anastasia R. Kovrizhina, Dmitriy N. Atochin, Andrei I. Khlebnikov
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2024-08-01
Colección:	Molecules
Materias:	c-Jun N-terminal kinase (JNK) inhibitor IQ-1 (11<i>H</i>-indeno[1,2-<i>b</i>]quinoxalin-11-one oxime) electron paramagnetic resonance nitric oxide donor spin trap hemoglobin
Acceso en línea:	https://www.mdpi.com/1420-3049/29/16/3820
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