MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease

Crohn’s disease (CD) is the chronic inflammation of the terminal ileum and colon triggered by a dysregulated immune response to bacteria, but insights into specific molecular perturbations at the critical bacteria-epithelium interface are limited. Here, we report that the membrane mucin MUC17 protec...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Elena Layunta, Sofia Jäverfelt, Fleur C. van de Koolwijk, Molly Sivertsson, Brendan Dolan, Liisa Arike, Sara I.M. Thulin, Bruce A. Vallance, Thaher Pelaseyed
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical investigation 2025-02-01
Schriftenreihe:	JCI Insight
Schlagworte:	Cell biology Gastroenterology
Online-Zugang:	https://doi.org/10.1172/jci.insight.181481
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