FTD-associated behavioural and transcriptomic abnormalities in ‘humanized’ progranulin-deficient mice: A novel model for progranulin-associated FTD

Frontotemporal dementia (FTD) is an early onset dementia characterized by neuropathology and behavioural changes. A common genetic cause of FTD is haploinsufficiency of the gene progranulin (GRN). Mouse models of progranulin deficiency have provided insight into progranulin neurobiology, but the des...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Benjamin Life, Terri L. Petkau, Giuliano N.F. Cruz, Erick I. Navarro-Delgado, Ning Shen, Keegan Korthauer, Blair R. Leavitt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-06-01
coleção:	Neurobiology of Disease
Assuntos:	Progranulin Frontotemporal dementia Humanized mice Preclinical model, RNAseq
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996123001523
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!